china anatase and rutile

In a 2017 study published in Scientific Reports, researchers exposed rats to human-relevant levels of E171 to examine the effects of intestinal inflammation and carcinogenesis. They saw that “a 100-day E171 treatment promoted colon microinflammation and initiated preneoplastic lesions while also fostering the growth of aberrant crypt foci in a chemically induced carcinogenesis model.” They continued: “Stimulation of immune cells isolated from Peyer’s Patches [which are clusters of lymphoid follicles found in the intestine] showed a decrease in Thelper (Th)-1 IFN-γ secretion, while splenic Th1/Th17 inflammatory responses sharply increased,” researchers wrote. “A 100-day titanium dioxide treatment promoted colon microinflammation and initiated preneoplastic lesions.” The scientists concluded: “These data should be considered for risk assessments of the susceptibility to Th17-driven autoimmune diseases and to colorectal cancer in humans exposed to TiO2 from dietary sources.”

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In addition to coated papers, titanium dioxide is also used in the production of specialty papers, such as those used for labels, packaging, and security documents. In these applications, titanium dioxide is added to the paper pulp to increase the opacity and brightness of the paper. This helps to create a more professional and appealing appearance for the final product, as well as providing enhanced security features through the use of fluorescent or UV-reactive titanium dioxide particles
titanium
titanium dioxide used in paper.

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